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Patrick Mehlen Selected Research

DCC Receptor

1/2021Netrin-1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson's disease features.
1/2020Netrin-1 and Its Receptor DCC Are Causally Implicated in Melanoma Progression.
12/2011DCC constrains tumour progression via its dependence receptor activity.
3/2007[Netrin-1 and axonal guidance: signaling and asymmetrical translation].
4/2005DCC association with lipid rafts is required for netrin-1-mediated axon guidance.
8/2004Role of the dependence receptor DCC in colorectal cancer pathogenesis.

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Patrick Mehlen Research Topics

Disease

50Neoplasms (Cancer)
11/2021 - 04/2003
24Colorectal Neoplasms (Colorectal Cancer)
01/2021 - 05/2002
12Carcinogenesis
03/2016 - 08/2004
8Inflammation (Inflammations)
11/2022 - 10/2008
8Neoplasm Metastasis (Metastasis)
01/2020 - 03/2008
5Neuroblastoma
01/2021 - 04/2009
5Breast Neoplasms (Breast Cancer)
01/2018 - 03/2008
4Alzheimer Disease (Alzheimer's Disease)
01/2017 - 03/2009
3Melanoma (Melanoma, Malignant)
01/2021 - 01/2019
3Pathologic Neovascularization
11/2016 - 04/2009
2Parkinson Disease (Parkinson's Disease)
01/2021 - 01/2021
2Lung Neoplasms (Lung Cancer)
01/2020 - 02/2009
2Amyloid Plaque
01/2017 - 08/2012
2Fibrosis (Cirrhosis)
06/2016 - 03/2016
2Infections
03/2016 - 11/2010
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2014 - 02/2009
2Ischemia
12/2011 - 09/2009
2Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
04/2010 - 10/2009
1Hyperplasia
11/2021
1Gigantism
11/2021
1Growth Hormone-Secreting Pituitary Adenoma
11/2021
1Prodromal Symptoms
01/2021
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
01/2021
1Constipation
01/2021
1Intestinal Neoplasms (Intestinal Cancer)
01/2020
1Retinal Degeneration
01/2020
1Ectodermal Dysplasia (Aplasia Cutis Congenita)
01/2019
1Fasciculation (Fasciculations)
01/2019
1Hepatocellular Carcinoma (Hepatoma)
01/2018
1Necrosis
09/2017
1Glioblastoma (Glioblastoma Multiforme)
04/2017
1Hepatitis C
06/2016
1Liver Diseases (Liver Disease)
05/2016
1Liver Cirrhosis (Hepatic Cirrhosis)
03/2016
1Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
02/2016
1Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
02/2016
1Brain Neoplasms (Brain Tumor)
01/2014
1Colonic Neoplasms (Colon Cancer)
02/2013
1Acute Kidney Injury (Acute Renal Failure)
12/2011
1Ulcerative Colitis
10/2009

Drug/Important Bio-Agent (IBA)

48Netrin-1IBA
11/2022 - 05/2002
25LigandsIBA
11/2021 - 01/2005
13Proteins (Proteins, Gene)FDA Link
11/2021 - 09/2004
6Netrin ReceptorsIBA
01/2021 - 04/2003
6DCC ReceptorIBA
01/2021 - 08/2004
4Amyloid (Amyloid Fibrils)IBA
01/2017 - 03/2009
3Laminin (Merosin)IBA
02/2012 - 04/2005
2Transcription Factors (Transcription Factor)IBA
01/2021 - 04/2010
2Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
01/2018 - 08/2006
2DecitabineFDA Link
02/2016 - 01/2016
2NetrinsIBA
01/2016 - 03/2007
2Peptides (Polypeptides)IBA
01/2016 - 08/2012
2Small Interfering RNA (siRNA)IBA
12/2013 - 02/2009
2Cisplatin (Platino)FDA LinkGeneric
12/2013 - 12/2011
2Nerve Growth Factor Receptors (Neurotrophin Receptors)IBA
07/2013 - 03/2009
2Nerve Growth Factor (NGF)IBA
07/2013 - 03/2009
2Caspase 3 (Caspase-3)IBA
12/2011 - 09/2009
2NF-kappa B (NF-kB)IBA
10/2009 - 10/2008
1Insulin-Like Growth Factor I (IGF-1)IBA
11/2021
1Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
11/2021
1EpitopesIBA
01/2021
1netrin-3IBA
01/2021
1SynucleinsIBA
01/2021
1Brain-Derived Neurotrophic Factor (BDNF)IBA
01/2021
1RotenoneIBA
01/2021
1neogeninIBA
01/2020
1Dacarbazine (DIC)FDA LinkGeneric
01/2020
1CytokinesIBA
01/2019
1Ectodysplasin ReceptorsIBA
01/2019
1Interleukin-6 (Interleukin 6)IBA
01/2019
1Phosphotransferases (Kinase)IBA
11/2018
1Stem Cell FactorIBA
11/2018
1Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)IBA
01/2018
1Messenger RNA (mRNA)IBA
01/2018
1CaspasesIBA
09/2017
1Caspase 9IBA
09/2017
1Ephrin-B3 (Ephrin B3)IBA
04/2017
1EphA4 ReceptorIBA
04/2017
1Jagged-1 ProteinIBA
01/2017
1Death-Associated Protein KinasesIBA
05/2016
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
01/2016
1Neutralizing AntibodiesIBA
01/2016
1Death Domain ReceptorsIBA
01/2016
1PhosphoserineIBA
10/2015
1MicroRNAs (MicroRNA)IBA
11/2014
1Biomarkers (Surrogate Marker)IBA
01/2014
1Paclitaxel (Taxol)FDA LinkGeneric
12/2013
1Fluorouracil (Carac)FDA LinkGeneric
12/2013
1Doxorubicin (Adriamycin)FDA LinkGeneric
12/2013
1Semaphorins (Semaphorin)IBA
11/2013
1plexinIBA
11/2013
1trkC ReceptorIBA
02/2013
1Bevacizumab (Avastin)FDA Link
12/2012
1Peptide Hydrolases (Proteases)FDA Link
08/2012
1Protein Isoforms (Isoforms)IBA
08/2012
1Nerve Growth Factors (Neurotrophins)IBA
07/2012
1Extracellular Matrix ProteinsIBA
03/2011
1CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)IBA
11/2010

Therapy/Procedure

8Therapeutics
11/2021 - 01/2010
1Drug Therapy (Chemotherapy)
04/2010